Straightforward and Highly Efficient Catalyst-Free One-Pot Synthesis of Dithiocarbamates under Solvent-Free Conditions

Najmedin Azizi,‡ Fezzeh Aryanasab,† and Mohammad R. Saidi*†
Department of Chemistry, Sharif University of Technology, P. O. Box 11465-9516, Tehran 11365, Iran, and Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran
Org. Lett., 2006, 8 (23), pp 5275–5277
DOI: 10.1021/ol0620141
Publication Date (Web): October 13, 2006
Copyright © 2006 American Chemical Society
‡

 Chemistry and Chemical Engineering Research Center of Iran.

,
†

 Sharif University of Technology.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, saidi@sharif.edu

Abstract

Abstract Image

A highly efficient and simple synthesis of dithiocarbamates is possible based on the one-pot reaction of amines, CS2, and alkyl halides without using a catalyst under solvent-free conditions. The mild reaction conditions, high yields, and broad scope of the reaction illustrate the good synthetic utility of this method. The reaction is a highly atom-economic process for production of S-alkyl thiocarbamates and successfully can be used in high quantities in the pharmaceutical or agrochemical industries.

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History

  • Published In Issue November 09, 2006
  • Received August 15, 2006

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