Total Synthesis of (±)-Morphine

Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan, and Tohru Fukuyama*
Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, and School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
Org. Lett., 2006, 8 (23), pp 5311–5313
DOI: 10.1021/ol062112m
Publication Date (Web): October 10, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, fukuyama@mol.f.u-tokyo.ac.jp

Abstract

Abstract Image

The morphinan skeleton was effectively synthesized by an intramolecular Mannich-type reaction. Further transformation led to total synthesis of morphine.

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History

  • Published In Issue November 09, 2006
  • Received August 28, 2006

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