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Letter

Synthesis of N-Substituted Indole Derivatives via PIFA-Mediated Intramolecular Cyclization

Supporting Info

Yunfei Du, Renhe Liu, Gregory Linn, and Kang Zhao*

College of Pharmaceuticals and Biotechnology, Tianjin University, 300072, PRC

Org. Lett., 2006, 8 (26), pp 5919–5922

DOI: 10.1021/ol062288o

Publication Date (Web): November 22, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, combinology@yahoo.com

Abstract

A variety of N-arylated and N-alkylated indole derivatives were synthesized by way of a phenyliodine bis(trifluoroacetate) (PIFA)-mediated intramolecular cyclization. This novel method allows for the construction of an indole skeleton by joining the N-atom on the side chain to the benzene ring at the last synthetic step. Other novel pyrrole-fused aromatic compounds can also be achieved by this method.

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Published In Issue December 21, 2006
Received September 17, 2006

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Letter

Synthesis of N-Substituted Indole Derivatives via PIFA-Mediated Intramolecular Cyclization

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Facile Synthesis of 1,2,3,4-Tetrahydro-β-carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic Cyclization

The Neber Route to Substituted Indoles

Palladium-Catalyzed Decarboxylative Coupling of Allylic Alkynoates with Arynes

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