1,1,1-Tris(hydroxymethyl)ethane as a New, Efficient, and Versatile Tripod Ligand for Copper-Catalyzed Cross-Coupling Reactions of Aryl Iodides with Amides, Thiols, and Phenols

Yao-Jung Chen* and Hsin-Hung Chen
Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan 402, ROC
Org. Lett., 2006, 8 (24), pp 5609–5612
DOI: 10.1021/ol062339h
Publication Date (Web): November 4, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, yjchen@dragon.nchu.edu.tw

Abstract

Abstract Image

1,1,1-Tris(hydroxymethyl)ethane was presented as a new, efficient, and versatile tridentate O-donor ligand suitable for the copper-catalyzed formation of C−N, C−S, and C−O bonds. This inexpensive and commercially available tripod ligand has been demonstrated to facilitate the copper-catalyzed cross-coupling reactions of aryl iodides with amides, thiols, and phenols to afford the corresponding desired products in good to excellent yields.

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History

  • Published In Issue November 23, 2006
  • Received September 22, 2006

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