Efficient and Stereoselective Synthesis of Allylic Ethers and Alcohols

Jiří Pospíšil and István E. Markó*
Dpartement de Chimie, Universit catholique de Louvain, Btiment Lavoisier, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium
Org. Lett., 2006, 8 (26), pp 5983–5986
DOI: 10.1021/ol062433y
Publication Date (Web): November 29, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, marko@chim.ucl.ac.be

Abstract

Abstract Image

A short and efficient synthesis of allylic TBS ethers and allylic alcohols has been developed, based upon a unique Kocienski−Julia olefination reaction. Allylic alcohols and allylic ethers are obtained in good to excellent yields and with high (E)-selectivity. The conditions are mild and the procedure is broadly applicable.

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History

  • Published In Issue December 21, 2006
  • Received October 3, 2006

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