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Letter

Iridium-Catalyzed Conversion of Alcohols into Amides via Oximes

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Nathan A. Owston,^† Alexandra J. Parker,^‡ and Jonathan M. J. Williams*^†

Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K., and Process Research and Development, AstraZeneca, Avlon Works, Severn Road, Hallen, Bristol BS10 7ZE, U.K.

Org. Lett., 2007, 9 (1), pp 73–75

DOI: 10.1021/ol062549u

Publication Date (Web): December 6, 2006

†

University of Bath.

‡

AstraZeneca.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, j.m.j.williams@bath.ac.uk

Abstract

The iridium catalyst [Ir(Cp*)Cl₂]₂ is effective for the rearrangement of oximes to furnish amides. The reaction has been combined with catalytic transfer hydrogenation between an alcohol and alkene to allow the conversion of alcohols into amides in a one-pot process.

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Published In Issue January 04, 2007
Received October 17, 2006

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Letter

Iridium-Catalyzed Conversion of Alcohols into Amides via Oximes

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Synthesis of Benzazoles by Hydrogen-Transfer Catalysis

Amide Synthesis from Alcohols and Amines by the Extrusion of Dihydrogen

Highly Efficient Ruthenium-Catalyzed Oxime to Amide Rearrangement

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