Silver(I) Triflate-Catalyzed Direct Synthesis of N-PMP Protected α-Aminopropargylphosphonates from Terminal Alkynes

Rajasekhar Dodda and Cong-Gui Zhao*
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249-0698
Org. Lett., 2007, 9 (1), pp 165–167
DOI: 10.1021/ol0627810
Publication Date (Web): December 1, 2006
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, cong.zhao@utsa.edu

Abstract

Abstract Image

N-PMP protected α-aminopropargylphosphonates have been synthesized by using a silver(I) triflate-catalyzed one-pot three-component reaction of terminal alkynes, p-anisidine, and diethyl formylphosphonate hydrate. Good to excellent yields of the desired products may be obtained with a very simple procedure.

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History

  • Published In Issue January 04, 2007
  • Received November 15, 2006

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