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Letter

Application of the Chiral Bis(phosphine) Monoxide Ligand to Catalytic Enantioselective Addition of Dialkylzinc Reagents to β-Nitroalkenes

Supporting Info

Alexandre Côté, Vincent N. G. Lindsay, and André B. Charette*

Dpartement de Chimie, Universit de Montral, P.O. Box 6128, Station Downtown, Montral, Qubec, Canada H3C 3J7

Org. Lett., 2007, 9 (1), pp 85–87

DOI: 10.1021/ol062792t

Publication Date (Web): December 15, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, andre.charette@umontreal.ca

Abstract

Me-DuPHOS monoxide is shown to be a very effective ligand in the enantioselective copper-catalyzed addition of dialkylzinc reagents to β-nitroalkenes providing access to chiral nitroalkanes. The major advantages of this process are high yields, broad and complementary substrate scope, and high enantioselectivities. The effect of achiral dummy ligands as an additive has also been documented.

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