Efficient Method for the Synthesis of Chiral Pyrrolidine Derivatives via Ring-Closing Enyne Metathesis Reaction

Qian Yang,†‡ Howard Alper,*† and Wen-Jing Xiao*‡;
Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada, and The Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
Org. Lett., 2007, 9 (5), pp 769–771
DOI: 10.1021/ol062959i
Publication Date (Web): February 6, 2007
Copyright © 2007 American Chemical Society
†

 University of Ottawa.

,
‡

 Central China Normal University.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, howard.alper@uottawa.ca, ; , wxiao@mail.ccnu.edu.cn

Abstract

Abstract Image

A series of new pyrrolidine derivatives were prepared directly in very good yields, from the substrates containing a basic or nucleophilic N atom via ring-closing enyne metathesis reaction under mild reaction conditions. Moreover, the reaction occurs smoothly without the presence of ethylene gas.

View: Full Text HTML | Hi-Res PDF

Tools

History

  • Published In Issue March 01, 2007
  • Received December 6, 2006

Recommend & Share

Related Content

Other ACS content by these authors: