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Letter

Direct C-Arylation of β-Enamino Esters and Ketones with Arynes

Supporting Info

Yeeman K. Ramtohul* and Anik Chartrand

Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co., Inc., P.O. Box 1005, 16711 Trans Canada Highway, Kirkland, Quebec, Canada H9H 3L1

Org. Lett., 2007, 9 (6), pp 1029–1032

DOI: 10.1021/ol063057k

Publication Date (Web): February 20, 2007

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, yeeman_ramtohul@merck.com

Abstract

An efficient, mild, and general method for the C-arylation of β-enamino esters and ketones with arynes has been developed. This methodology provides a facile and direct access to a variety of substituted aromatic β-enamino compounds in moderate to excellent yield.

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Published In Issue March 15, 2007
Received December 18, 2006

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Letter

Direct C-Arylation of β-Enamino Esters and Ketones with Arynes

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Easily Attachable and Detachable ortho-Directing Agent for Arylboronic Acids in Ruthenium-Catalyzed Aromatic C−H Silylation

Enantiospecific Total Syntheses of Kapakahines B and F

Double Bond Isomerization/Enantioselective Aza-Petasis−Ferrier Rearrangement Sequence as an Efficient Entry to Anti- and Enantioenriched β-Amino Aldehydes

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