Direct Intermolecular Hydroacylation of N,N-Dialkylacrylamides with Aldehydes Catalyzed by a Cationic Rhodium(I)/dppb Complex

Ken Tanaka,* Yu Shibata, Takeshi Suda, Yuji Hagiwara, and Masao Hirano
Department of Applied Chemistry, Graduate School of Engineering, and Instrumentation Analysis Center, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan
Org. Lett., 2007, 9 (7), pp 1215–1218
DOI: 10.1021/ol070153s
Publication Date (Web): March 7, 2007
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, tanaka-k@cc.tuat.ac.jp

Abstract

Abstract Image

A cationic rhodium(I)/dppb complex catalyzed direct intermolecular hydroacylation of N,N-dialkylacrylamides with both aliphatic and aromatic aldehydes has been achieved through the stabilization of acylrhodium intermediates by alkene chelation to rhodium. This method represents a versatile new route to γ-ketoamides in view of the high atom economy and commercial availability of substrates.

View: Full Text HTML | Hi-Res PDF

Tools

History

  • Published In Issue March 29, 2007
  • Received January 20, 2007

Recommend & Share

Related Content

Other ACS content by these authors: