Pt-Catalyzed Cyclization/1,2-Migration for the Synthesis of Indolizines, Pyrrolones, and Indolizinones

Cameron R. Smith, Eric M. Bunnelle, Allison J. Rhodes, and Richmond Sarpong*
Department of Chemistry, University of California, Berkeley, California 94720
Org. Lett., 2007, 9 (6), pp 1169–1171
DOI: 10.1021/ol0701971
Publication Date (Web): February 20, 2007
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, rsarpong@berkeley.edu

Abstract

Abstract Image

Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily available substrates.

Tools

History

  • Published In Issue March 15, 2007
  • Received January 25, 2007

Recommend & Share

Related Content

Other ACS content by these authors: