Low-Valent Niobium-Catalyzed Reduction of α,α,α-Trifluorotoluenes

Kohei Fuchibe, Yoshitaka Ohshima, Ken Mitomi, and Takahiko Akiyama*
Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro Toshima-ku, Tokyo 171-8588, Japan
Org. Lett., 2007, 9 (8), pp 1497–1499
DOI: 10.1021/ol070249m
Publication Date (Web): March 13, 2007
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, takahiko.akiyama@gakushuin.ac.jp

Abstract

Abstract Image

In the presence of 5 mol % of niobium(V) chloride, α,α,α-trifluorotoluene derivatives were reduced with lithium aluminum hydride to give toluene derivatives in good yields. Stepwise, partial reduction of bis(trifluoromethyl)benzene derivative was also demonstrated.

Tools

History

  • Published In Issue April 12, 2007
  • Received February 1, 2007

Recommend & Share

Related Content

Other ACS content by these authors: