Nickel-Catalyzed 1,4-Addition of Trialkylboranes to α,β-Unsaturated Esters:  Dramatic Enhancement by Addition of Methanol

Koji Hirano, Hideki Yorimitsu,* and Koichiro Oshima*;
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
Org. Lett., 2007, 9 (8), pp 1541–1544
DOI: 10.1021/ol070288y
Publication Date (Web): March 16, 2007
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, oshima@orgrxn.mbox.media.kyoto-u.ac.jp, ; , yori@orgrxn.mbox.media.kyoto-u.ac.jp

Abstract

Abstract Image

Nickel catalyst systems for 1,4-addition of trialkylboranes to α,β-unsaturated esters have been developed. Addition of methanol was found to be essential for the alkylation reaction with 9-alkyl-9-BBNs.

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History

  • Published In Issue April 12, 2007
  • Received February 5, 2007

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