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Letter

Copper-Catalyzed Highly Efficient Multicomponent Reactions: Synthesis of 2-(Sulfonylimino)-4-(alkylimino)azetidine Derivatives

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Xiaoliang Xu,*^† Dongping Cheng,^‡ Jinghua Li,^‡ Hongyun Guo,^† and Jie Yan^†

College of Chemical Engineering and Materials Science and College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China

Org. Lett., 2007, 9 (8), pp 1585–1587

DOI: 10.1021/ol070485x

Publication Date (Web): March 24, 2007

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

†

College of Chemical Engineering and Materials Science.

‡

College of Pharmaceutical Science.

, xuxiaoliang@zjut.edu.cn

Abstract

Under very mild conditions, functionalized 2-(sulfonylimino)-4-(alkylimino)azetidine derivatives were prepared in good to excellent yields via a copper-catalyzed multicomponent reaction of readily available terminal alkynes, sulfonyl azides, and carbodiimides without the assistance of a base. The mechanism may be through a [2 + 2] cycloaddition.

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Published In Issue April 12, 2007
Received February 26, 2007

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Letter

Copper-Catalyzed Highly Efficient Multicomponent Reactions: Synthesis of 2-(Sulfonylimino)-4-(alkylimino)azetidine Derivatives

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Copper-Catalyzed Hydrative Amide Synthesis with Terminal Alkyne, Sulfonyl Azide, and Water

Novel and Efficient Synthesis of Iminocoumarins via Copper-Catalyzed Multicomponent Reaction

Highly Efficient One-Pot Synthesis of N-Sulfonylamidines by Cu-Catalyzed Three-Component Coupling of Sulfonyl Azide, Alkyne, and Amine

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