An Efficient Synthesis of Nitroalkenes by Alkene Cross Metathesis:  Facile Access to Small Ring Systems

Graham P. Marsh,† Philip J. Parsons,*† Clive McCarthy,‡ and Xavier G. Corniquet†
Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QJ, United Kingdom, and Novartis Institutes for Biomedical Research, Lichtstrasse 35, CH-4056 Basel, CH, Switzerland
Org. Lett., 2007, 9 (14), pp 2613–2616
DOI: 10.1021/ol070557k
Publication Date (Web): June 6, 2007
Copyright © 2007 American Chemical Society
†

 University of Sussex.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

,
‡

 Novartis.

, p.j.parsons@sussex.ac.uk

Abstract

Abstract Image

A synthesis of highly functionalized nitroalkenes is reported that utilizes a cross metathesis (CM) reaction between simple aliphatic nitro compounds and a range of substituted alkenes. This chemistry offers a simple and attractive route to nitroalkenes that would otherwise be difficult to prepare, and that have a very useful application as precursors to a variety of heterocyclic entities.

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History

  • Published In Issue July 05, 2007
  • Received March 6, 2007

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