Catalytic Asymmetric Formation of β-Sultams

Marian Zajac and René Peters*
Laboratory of Organic Chemistry, ETH Zrich, Wolfgang-Pauli-Strasse 10, Hnggerberg HCI E 111, CH-8093 Zrich, Switzerland
Org. Lett., 2007, 9 (10), pp 2007–2010
DOI: 10.1021/ol070644c
Publication Date (Web): April 21, 2007
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, peters@org.chem.ethz.ch

Abstract

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β-Sultams, highly strained sulfonyl analogues of β-lactams, were prepared enantio- and diastereoselectively by tertiary amine catalyzed [2 + 2] cycloaddition reactions. The title compounds are practical precursors of highly enantioenriched biologically interesting β-aminosulfonyl derivatives.

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History

  • Published In Issue May 10, 2007
  • Received March 16, 2007

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