Copper-Catalyzed Asymmetric Reduction of 3,3-Diarylacrylonitriles

Daehyung Lee, Youngmin Yang, and Jaesook Yun*
Department of Chemistry and Institute of Basic Science, Sungkyunkwan University, Suwon 440-746, Korea
Org. Lett., 2007, 9 (14), pp 2749–2751
DOI: 10.1021/ol0712071
Publication Date (Web): June 8, 2007
Copyright © 2007 American Chemical Society

Abstract

Abstract Image

CuH-catalyzed enantioselective conjugate reduction of 3,3-diaryl-substituted acrylonitriles is described. A range of 3-aryl-3-pyridylacrylonitriles were reduced with high levels of enantioselectivity under optimal conditions employing a copper/Josiphos complex in the presence of polymethylhydrosiloxane (PMHS).

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History

  • Published In Issue July 05, 2007
  • Received May 22, 2007

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