Letter
Copper-Catalyzed Asymmetric Reduction of 3,3-Diarylacrylonitriles
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Abstract

CuH-catalyzed enantioselective conjugate reduction of 3,3-diaryl-substituted acrylonitriles is described. A range of 3-aryl-3-pyridylacrylonitriles were reduced with high levels of enantioselectivity under optimal conditions employing a copper/Josiphos complex in the presence of polymethylhydrosiloxane (PMHS).
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History
- Published In Issue July 05, 2007
- Received May 22, 2007
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