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Letter

Expedient Preparation of Trifluoromethyl-Substituted Benzofuranols

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Bill Morandi and Erick M. Carreira*

Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland

Org. Lett., 2011, 13 (22), pp 5984–5985

DOI: 10.1021/ol202423s

Publication Date (Web): October 20, 2011

carreira@org.chem.ethz.ch

Section:

Heterocyclic Compounds (One Hetero Atom)

Abstract

Direct access to 3-trifluoromethyl-substituted benzofuranols is presented. The products are obtained in good yields from commercially available salicylaldehydes by using in situ generated trifluoromethyl diazomethane and boron trifluoride as an activator. As shown in a representative example, the products can be transformed into the corresponding trifluoromethyl-substituted benzofurans.

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History

Published In Issue November 18, 2011
Article ASAPOctober 20, 2011
Received: September 07, 2011

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Letter

Expedient Preparation of Trifluoromethyl-Substituted Benzofuranols

Abstract

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History

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