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Letter

Synthesis of Novel Azaspiro[3.4]octanes as Multifunctional Modules in Drug Discovery

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Dong Bo Li^†, Mark Rogers-Evans*^‡, and Erick M. Carreira*^†

Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland, and Discovery Research, Chemistry Technologies & Innovation, F. Hoffmann-La Roche AG, CH-4070 Basel, Switzerland

Org. Lett., 2011, 13 (22), pp 6134–6136

DOI: 10.1021/ol2025313

Publication Date (Web): October 18, 2011

mark.rogers-evans@roche.com; carreira@org.chem.ethz.ch,

ETH Zürich.

F. Hoffmann-La Roche AG.

Section:

Heterocyclic Compounds (One Hetero Atom)

Abstract

Step-economic and scalable syntheses of novel thia-azaspiro[3.4]octanes are reported. These spirocycles and some related intermediates can serve as uncharted multifunctional modules for drug discovery chemistry.

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History

Published In Issue November 18, 2011
Article ASAPOctober 18, 2011
Received: September 19, 2011

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Letter

Synthesis of Novel Azaspiro[3.4]octanes as Multifunctional Modules in Drug Discovery

Abstract

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Related Content

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