Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks

Johannes A. Burkhard, Carine Guérot, Henner Knust, and Erick M. Carreira*
Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland, and F. Hoffmann-La Roche AG, pRED, Discovery Chemistry, CH-4070 Basel, Switzerland
Org. Lett., 2012, 14 (1), pp 66–69
DOI: 10.1021/ol2028459
Publication Date (Web): November 23, 2011
Copyright © 2011 American Chemical Society
carreira@org.chem.ethz.ch, †

ETH Zurich.

, ‡

F. Hoffmann-La Roche AG.

Abstract

Abstract Image

The preparation of versatile azaspiro[3.3]heptanes carrying multiple exit vectors is disclosed. Expedient synthetic routes enable the straightforward access to these novel modules that are expected to have significance in drug discovery and design.

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History

  • Published In Issue January 06, 2012
  • Article ASAPNovember 23, 2011
  • Received: October 21, 2011

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