The Redox-Mannich Reaction

Weijie Chen and Daniel Seidel^*

Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States

Org. Lett., 2014, 16 (11), pp 3158–3161

DOI: 10.1021/ol501365j

Publication Date (Web): May 23, 2014

*E-mail: seidel@rutchem.rutgers.edu.

ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

Abstract

A complement to the classic three-component Mannich reaction, the redox-Mannich reaction, utilizes the same starting materials but incorporates an isomerization step that enables the facile preparation of ring-substituted β-amino ketones. Reactions occur under relatively mild conditions and are facilitated by benzoic acid.

Supporting Information

Experimental procedures and characterization data. This material is available free of charge via the Internet at http://pubs.acs.org.

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Letter

The Redox-Mannich Reaction

Abstract

Supporting Information

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ChemInform Abstract: The Redox-Mannich Reaction.

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Letter

The Redox-Mannich Reaction

Abstract

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