Letter
A Novel Practical Synthesis of Benzothiazoles via Pd-Catalyzed Thiol Cross-Coupling
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Abstract

A convenient synthesis of substituted benzothiazoles from 2-bromoanilides has been accomplished. The various 2-bromoanilides were reacted with an alkyl thiolate in high yields using a palladium catalyst. The resulting sulfides were easily converted to the corresponding benzothiazoles via the simultaneous generation of thiols and condensation under basic or acidic conditions.
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History
- Published In Issue August 30, 2007
- Received July 4, 2007
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