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Ir-Catalyzed Regio- and Enantioselective Decarboxylative Allylic Alkylations

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Hu He, Xiao-Jian Zheng, Yi Li, Li-Xin Dai, and Shu-Li You*

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China

Org. Lett., 2007, 9 (21), pp 4339–4341

DOI: 10.1021/ol7019394

Publication Date (Web): September 14, 2007

Section:

Aliphatic Compounds

Abstract

[Ir(COD)Cl]₂/phosphoramidite ligand 1a was found to be an efficient catalytic system for the highly regio- and enantioselective decarboxylative alkylation of γ-substituted allyl β-ketocarboxylates, affording the branched products with up to >99/1 branched-linear ratio and 96% ee.

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This article has been cited by 13 ACS Journal articles (5 most recent appear below).

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