Intramolecular Cycloaddition of Azomethine Ylides in the Preparation of Pyrrolidino[2‘,3‘:3,4]pyrrolidino[1,2- a]benzimidazoles

Liping Meng, James C. Fettinger, and Mark J. Kurth*
Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616
Org. Lett., 2007, 9 (24), pp 5055–5058
DOI: 10.1021/ol702301n
Publication Date (Web): November 1, 2007
Copyright © 2007 American Chemical Society

Abstract

Abstract Image

The parent pyrrolidino[2‘,3‘:3,4]pyrrolidino[1,2-a]benzimidazole heterocycle as well as a series of novel analogues have been synthesized utilizing a microwave-assisted intramolecular cycloaddition of azomethine ylides as the key transformation. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.

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History

  • Published In Issue November 22, 2007
  • Received September 21, 2007

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