Biaryl Synthesis via Palladium-Catalyzed Aryne Multicomponent Coupling

Jaclyn L. Henderson,† Andrew S. Edwards,‡ and Michael F. Greaney*†
University of Edinburgh, School of Chemistry, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, U.K., and Organon Laboratories Ltd., Newhouse, Lanarkshire ML1 5SH, U.K.
Org. Lett., 2007, 9 (26), pp 5589–5592
DOI: 10.1021/ol702584t
Publication Date (Web): November 22, 2007
Copyright © 2007 American Chemical Society
†

 University of Edinburgh.

,
‡

 Organon Laboratories.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, michael.greaney@ed.ac.uk

Abstract

Abstract Image

Aryl iodides have been introduced as electrophiles in the three-component Heck coupling of arynes. Following optimization studies to favor three- versus two-component coupling, the reaction proceeds in good yield to afford a variety of functionalized biaryls.

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History

  • Published In Issue December 20, 2007
  • Received October 26, 2007

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