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Letter

Highly Ortho-Selective Cross-Coupling of Dichlorobenzene Derivatives with Grignard Reagents

Supporting Info

Shunpei Ishikawa and Kei Manabe*

RIKEN, 2-1 Hirosawa, Wako 351-0198, Japan

Org. Lett., 2007, 9 (26), pp 5593–5595

DOI: 10.1021/ol702646s

Publication Date (Web): November 17, 2007

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, keimanabe@riken.jp

Abstract

Highly ortho-selective cross-coupling of dichlorobenzene derivatives with Grignard reagents was realized using a combination of Pd₂(dba)₃ and PCy₃. Use of hydroxylated terphenylphosphines further improved the reactions of dichlorophenol and dichloroaniline.

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Published In Issue December 20, 2007
Received November 1, 2007

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Letter

Highly Ortho-Selective Cross-Coupling of Dichlorobenzene Derivatives with Grignard Reagents

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

High Ortho Preference in Ni-Catalyzed Cross-Coupling of Halophenols with Alkyl Grignard Reagents

C−F Bond Activation in Organic Synthesis

Directed Carbozincation Reactions of Cyclopropene Derivatives

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