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Addition of Amines to Nitriles Catalyzed by Ytterbium Amides: An Efficient One-Step Synthesis of Monosubstituted N-Arylamidines

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Junfeng Wang,^† Fan Xu,^† Tao Cai,^† and Qi Shen*^†^‡

Key Laboratory of Organic Synthesis of Jiangsu Province, Department of Chemistry and Chemical Engineering, Dushu Lake Campus, Suzhou University, Suzhou 215123, People's Republic of China, and State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Org. Lett., 2008, 10 (3), pp 445–448

DOI: 10.1021/ol702739c

Publication Date (Web): January 4, 2008

Section:

Benzene, Its Derivatives, and Condensed Benzenoid Compounds

Abstract

A one-step synthesis of monosubstituted N-arylamidinates via addition of amines to nitriles catalyzed by ytterbium amides is reported. The reactions with various substrates give the products in good to excellent yields with 5 mol % ytterbium at 100 °C under solvent-free conditions.

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Citing Articles

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This article has been cited by 13 ACS Journal articles (5 most recent appear below).

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