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Letter

Heck Couplings at Room Temperature in Nanometer Aqueous Micelles^†

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Bruce H. Lipshutz* and Benjamin R. Taft

Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106

Org. Lett., 2008, 10 (7), pp 1329–1332

DOI: 10.1021/ol702755g

Publication Date (Web): March 12, 2008

Section:

General Organic Chemistry

Abstract

A nonionic amphiphile such as Triton X-100 or the vitamin E-based PTS, both of which form nanomicelles in water, promotes Heck cross-couplings of non-water-soluble partners at ambient temperatures. These are the first examples of Heck reactions conducted in water (as the only solvent) at room temperature.

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History

Published In Issue April 03, 2008
Received November 14, 2007

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Letter

Heck Couplings at Room Temperature in Nanometer Aqueous Micelles^†