Air- and Water-Stable Catalysts for Hydroamination/Cyclization. Synthesis and Application of CCC−NHC Pincer Complexes of Rh and Ir

Eike B. Bauer,‡§ G. T. Senthil Andavan,‡ T. Keith Hollis,†‡* Ramel J. Rubio,‡ Joon Cho,†‡ Glenn R. Kuchenbeiser,‡ Theodore R. Helgert,† Christopher S. Letko,‡ and Fook S. Tham‡
Department of Chemistry and Biochemistry, The University of Mississippi, University, Mississippi, 38677, and Department of Chemistry, University of California, Riverside, California 92521
Org. Lett., 2008, 10 (6), pp 1175–1178
DOI: 10.1021/ol8000766
Publication Date (Web): February 23, 2008
Copyright © 2008 American Chemical Society
‡

 University of California, Riverside.

,
§

 Current address:  Department of Chemistry and Bioshemistry, University of Missouri, St. Louis, One University Boulevard, St. Louis, MO 63121.

,

 Current address:  Department of Chemistry, Northwestern University, Evanston, Illinois 60208.

,
†

 The University of Mississippi.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

,

 Current address:  Joint Sciences Department, The Claremont Colleges, W. M. Keck Science Center, 925 N. Mills Avenue, Claremont, CA 91711.

, hollis@olemiss.edu

Abstract

Abstract Image

The scope of CCC−NHC pincer complex synthetic methodology by metalation/transmetalation has been extended to Ir. Structural characterization revealed that it is isomorphous with the Rh complex. Both Rh and Ir complexes are efficient catalysts for the hydroamination/cyclization of secondary amines in the presence of air and/or water.

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History

  • Published In Issue March 20, 2008
  • Received January 11, 2008

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