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Letter

Direct Synthesis of 1,3-Diketones by Rh-Catalyzed Reductive α-Acylation of Enones

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Kazuyuki Sato, Satoshi Yamazoe, Rie Yamamoto, Shizuka Ohata, Atsushi Tarui, Masaaki Omote, Itsumaro Kumadaki and Akira Ando

Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan

Org. Lett., 2008, 10 (12), pp 2405–2408

DOI: 10.1021/ol800660y

Publication Date (Web): May 14, 2008

Abstract

1,3-Diketones were synthesized from α,β-unsaturated ketones by treatment with acid chlorides and Et₂Zn in the presence of RhCl(PPh₃)₃. This is a very simple and extremely chemoselective reaction to give the adduct at the α-position of α,β-unsaturated ketones.

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Published In Issue June 19, 2008
Article ASAPMay 14, 2008
Received: March 21, 2008

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Letter

Direct Synthesis of 1,3-Diketones by Rh-Catalyzed Reductive α-Acylation of Enones

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Related Content

Direct Carbon−Carbon Bond Formation via Soft Enolization: A Facile and Efficient Synthesis of 1,3-Diketones

A Tandem Reaction Initiated by 1,4-Addition of Bis(iodozincio)methane for 1,3-Diketone Formation

Nickel-Catalyzed Heck-Type Reactions of Benzyl Chlorides and Simple Olefins

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