Assisted Ruthenium-Catalyzed C−H Bond Activation: Carboxylic Acids as Cocatalysts for Generally Applicable Direct Arylations in Apolar Solvents

Lutz Ackermann, Rubn Vicente and Andreas Althammer
Institut fr Organische und Biomolekulare Chemie, Georg-August-Universitaet, Tammannstrasse 2, 37077 Goettingen, Germany
Org. Lett., 2008, 10 (11), pp 2299–2302
DOI: 10.1021/ol800773x
Publication Date (Web): April 26, 2008
Copyright © 2008 American Chemical Society

Abstract

Abstract Image

Catalytic amounts of aromatic carboxylic acid MesCO2H enabled efficient ruthenium-catalyzed direct arylations in apolar solvents with unparalleled broad scope via a concerted deprotonation−metalation mechanism.

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History

  • Published In Issue June 05, 2008
  • Article ASAPApril 26, 2008
  • Received: April 04, 2008

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