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Copper-Catalyzed “Click” Reaction/Direct Arylation Sequence: Modular Syntheses of 1,2,3-Triazoles
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Abstract
Inexpensive copper catalysts enabled modular one-pot multicomponent syntheses of fully decorated triazoles through a sustainable “click” reaction/direct arylation sequence.
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This article has been cited by 33 ACS Journal articles (5 most recent appear below).
Convergent, Fit-For-Purpose, Kilogram-Scale Synthesis of a 5-Lipoxygenase Inhibitor
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Cu(II) Catalyzed Imine C–H Functionalization Leading to Synthesis of 2,5-Substituted 1,3,4-Oxadiazoles
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Srimanta Guin, Tuhin Ghosh, Saroj Kumar Rout, Arghya Banerjee, and Bhisma K. PatelOrganic Letters2011 13 (22), 5976-5979A direct access to symmetrical and unsymmetrical 2,5-disubstituted [1,3,4]-oxadiazoles has been accomplished through an imine C–H functionalization of N-arylidenearoylhydrazide using a catalytic quantity of Cu(OTf)2. This is the first example of amidic ...
Copper-Mediated C–H Activation/C–S Cross-Coupling of Heterocycles with Thiols
Sadananda Ranjit, Richmond Lee, Dodi Heryadi, Chao Shen, Ji’En Wu, Pengfei Zhang, Kuo-Wei Huang, and Xiaogang LiuThe Journal of Organic Chemistry2011 76 (21), 8999-9007Copper-Mediated C–H Activation/C–S Cross-Coupling of Heterocycles with Thiols
Sadananda Ranjit, Richmond Lee, Dodi Heryadi, Chao Shen, Ji’En Wu, Pengfei Zhang, Kuo-Wei Huang, and Xiaogang LiuThe Journal of Organic Chemistry2011 76 (21), 8999-9007We report the synthesis of a series of aryl- or alkyl-substituted 2-mercaptobenzothiazoles by direct thiolation of benzothiazoles with aryl or alkyl thiols via copper-mediated aerobic C–H bond activation in the presence of stoichiometric CuI, 2,2′-...
Ligand-Free Copper-Catalyzed Regioselective C-2 Arylation of Imidazo[2,1-b]thiazoles
Guoli Huang, Hongsheng Sun, Xiaojie Qiu, Can Jin, Chen Lin, Yingzhong Shen, Juli Jiang, and Leyong WangOrganic Letters2011 13 (19), 5224-5227Ligand-Free Copper-Catalyzed Regioselective C-2 Arylation of Imidazo[2,1-b]thiazoles
Guoli Huang, Hongsheng Sun, Xiaojie Qiu, Can Jin, Chen Lin, Yingzhong Shen, Juli Jiang, and Leyong WangOrganic Letters2011 13 (19), 5224-5227An effective, regioselective C-2 arylation of imidazo[2,1-b]thiazoles catalyzed by Cu(I) has been developed. This arylation proceeded smoothly without promotion of the ligands, and various functional (22 samples) groups were well tolerated. Preliminary ...
A General Method for Copper-Catalyzed Arene Cross-Dimerization
Hien-Quang Do and Olafs DaugulisJournal of the American Chemical Society2011 133 (34), 13577-13586A General Method for Copper-Catalyzed Arene Cross-Dimerization
Hien-Quang Do and Olafs DaugulisJournal of the American Chemical Society2011 133 (34), 13577-13586A general method for a highly regioselective copper-catalyzed cross-coupling of two aromatic compounds using iodine as an oxidant has been developed. The reactions involve an initial iodination of one arene followed by arylation of the most acidic C–H ...
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History
- Published In Issue July 17, 2008
- Article ASAPJune 13, 2008
- Received: May 09, 2008
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