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Letter

HRMS Directly From TLC Slides. A Powerful Tool for Rapid Analysis of Organic Mixtures

Natalie J. Smith, Marek A. Domin and Lawrence T. Scott

Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467-3860

Org. Lett., 2008, 10 (16), pp 3493–3496

DOI: 10.1021/ol8012759

Publication Date (Web): July 16, 2008

Abstract

High-resolution mass spectra (HRMS) of individual spots on thin-layer chromatography (TLC) slides can now be obtained quickly and easily at atmospheric pressure, with zero sample preparation, using commercially available instrumentation. The method is complementary to GC−mass spectrometry but is not limited to compounds of high volatility and high thermal stability. TLC−HRMS can be used to monitor chemical reactions in real time and has the capacity thereby to accelerate significantly the pace of synthetic organic chemistry.