The Urea−Hydrogen Peroxide Complex:  Solid-State Oxidative Protocols for Hydroxylated Aldehydes and Ketones (Dakin Reaction), Nitriles, Sulfides, and Nitrogen Heterocycles

Rajender S. Varma* and Kannan P. Naicker
Department of Chemistry and Texas Research Institute for Environmental Studies (TRIES), Sam Houston State University, Huntsville, Texas 77341-2117
Org. Lett., 1999, 1 (2), pp 189–192
DOI: 10.1021/ol990522n
Publication Date (Web): May 29, 1999
Copyright © 1999 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, chm_rsv@shsu.edu

Abstract

Abstract Image

An efficient solid-state oxidation of organic molecules is described using a stable, inexpensive, and easily handled reagent, the urea−hydrogen peroxide adduct. The generality of the reaction has been demonstrated in oxidation of several molecules, namely hydroxylated aldehydes and ketones (to hydroxylated phenols), sulfides (to sulfoxides and sulfones), nitriles (to amides), and nitrogen heterocycles (to N-oxides).

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History

  • Published In Issue July 29, 1999
  • Received March 16, 1999

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