Article
Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 2: Synthesis of Fragments C1-6 and C9-14
Corresponding author: E-mail: stuart_john.mickel@pharma.novartis.com.
Abstract

Kilogram-scale syntheses of fragments C1-6 (6) and C9-14 (4) of (+)-discodermolide from common precursor 3 are described. Improved procedures for each step of both fragments were developed by minimizing or eliminating the formation of byproducts that were isolated and characterized in Smith's synthesis.
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History
- Published In Issue January 16, 2004
- Received for review September 16, 2003.
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