Combined Effect of Gender and Caloric Restriction on Liver Proteomic Expression Profile

Adamo Valle*†‡, Elena Silvestri‡§, Maria Moreno§, Angela Chambery, Jordi Oliver†, Pilar Roca† and Fernando Goglia§
Grup de Metabolisme Energtic i Nutrici, Departament de Biologia Fonamental i Cincies de la Salut, Institut Universitari d’Investigaci en Cincies de la Salut (IUNICS), Universitat de les Illes Balears, Carretera Valldeomssa Km 7.5, 07122 Palma de Mallorca, Spain, Dipartamento di Scienze Biologiche ed Ambientali, Universit degli Studi del Sannio, Via Port′ Arsa 11, 82100 Benevento, Italy, and Dipartimento di Scienze della Vita, Seconda Univesit di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
J. Proteome Res., 2008, 7 (7), pp 2872–2881
DOI: 10.1021/pr800086t
Publication Date (Web): May 28, 2008
Copyright © 2008 American Chemical Society
* To whom correspondence should be addressed. Dr. Adamo Valle, Dept. Biologia Fonamental I Cincies de la Salut, Universitat de les Illes Balears. Cra. Valldemossa km 7.5 E-07122-Palma de Mallorca, Spain. Fax: +34 971 173 184. E-mail: vdbsavg4@uib.es.
,
†

Universitat de les Illes Balears.

,
‡

These authors contributed equally to the manuscript.

,
§

Universit degli Studi del Sannio.

,

Seconda Univesit di Napoli.

Abstract

Abstract Image

We analyzed the combined effect of gender and CR on protein expression profile in liver. We identified 27 differentially expressed proteins involved in several cellular functions such as substrate metabolism, antioxidant systems, stress response, iron homeostasis and cardiovascular protection. This study reveals new cellular pathways liable to be similarly regulated in females and calorie restricted rats and which could be related with the greater longevity in these animals.

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History

  • Published In Issue July 03, 2008
  • Article ASAPMay 28, 2008
  • Received: February 1, 2008

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