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Perspective

Future of ToxicologyLipid Peroxidation in the Future: From Biomarker to Etiology

Supporting Info

Koji Uchida*

Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan

Chem. Res. Toxicol., 2007, 20 (1), pp 3–5

DOI: 10.1021/tx600304n

Publication Date (Web): December 5, 2006

To whom correspondence should be addressed. Tel: 81-52-789-4127. Fax: 81-52-789-5741. E-mail: uchidak@agr.nagoya-u.ac.jp.

Abstract

On the basis of a large number of reports concerning the detection of lipid peroxidation products as biomarkers in human diseases, there is no doubt that their steady-state levels increase under pathophysiological states associated with oxidative stress. The key question is whether they play any causative roles. This may be a matter of primary concern, which represents an important direction to pursue in the future of toxicology. My latest approach from autoimmune response induced by lipid peroxidation products will be illustrated.

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