The Chemical Toxicology of 2-Deoxyribose Oxidation in DNA

Peter C. Dedon*
Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, NE47-277, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139
Chem. Res. Toxicol., 2008, 21 (1), pp 206–219
DOI: 10.1021/tx700283c
Publication Date (Web): December 4, 2007
Copyright © 2008 American Chemical Society
* To whom correspondence should be addressed. Tel: 617-253-8017 . Fax: 617-324-7554. E-mail: pcdedon@mit.edu.
This article is part of the CRT 20th Anniversary Special Issue special issue.

Abstract

Abstract Image

Damage to DNA and RNA caused by oxidative mechanisms has been well-studied for its potential role in the development of human disease. Only recently, though, have we begun to appreciate that oxidation of the 2-deoxyribose moiety in DNA is also a determinant of the genetic toxicology of oxidative stress and inflammation, with involvement in more than just “strand breaks”, such as complex DNA lesions, protein–DNA cross-links, and protein and DNA adducts. As an update to a 1992 review of 2′-deoxyribose oxidation by bleomycin and the enediynes published in Chemical Research in Toxicology [Dedon, P. C., and Goldberg, I. H. (1992) Chem. Res. Toxicol. 5, 311–332], this review focuses on recent developments in the chemical biology, bioanalytical chemistry, and genetic toxicology of 2-deoxyribose oxidation products in DNA under biologically relevant conditions.

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History

  • Published In Issue January 21, 2008
  • Article ASAPDecember 04, 2007
  • Received: August 5, 2007
    Accepted:  ,
    Revised:  ,

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