Brief Communication

Nucleophilic 1,1-Difluoroethylation with Fluorinated Phosphonium Salt

Key Laboratory of Organofluorine Chemistry, Shanghai Institute Of Organic Chmistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, P. R. China
J. Org. Chem., 2016, 81 (24), pp 12084–12090
DOI: 10.1021/acs.joc.6b02723
Publication Date (Web): December 3, 2016
Copyright © 2016 American Chemical Society
*E-mail: jlin@sioc.ac.cn. Fax: +86-21-6416-6128. Tel: +86-21-5492-5541., *E-mail: jchxiao@sioc.ac.cn. Fax: +86-21-6416-6128. Tel: +86-21-5492-5340.

Abstract

Abstract Image

The fluorinated phosphonium salt (Ph3P+CF2CH3 BF4) was shown to act as a nucleophilic 1,1-difluoroethylation agent to enable difluoroethylation of aldehydes and imines.

Supporting Information


The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.joc.6b02723.

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Article Views: 786 Times
Received 11 November 2016
Published online 3 December 2016
Published in print 16 December 2016
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