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Proteases Universally Recognize Beta Strands In Their Active Sites

Centre for Drug Design and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, Qld 4072, Australia
Chem. Rev., 2005, 105 (3), pp 973–1000
DOI: 10.1021/cr040669e
Publication Date (Web): February 16, 2005
Copyright © 2005 American Chemical Society

Joel Tyndall obtained his B.Sc. (Hons) degree in Inorganic Chemistry from Monash University in 1994 and his Ph.D. degree in 2000 from the Centre for Drug Design and Development, The University of Queensland, which focused on molecular recognition in disease. He spent a year at the University of Edinburgh with Professor Malcolm Walkinshaw. Since 2001 he has worked with Professor Fairlie in the field of drug design. He took up a faculty position in 2004 at the School of Pharmacy at Otago University, New Zealand.

Tessa Nall was born in Brisbane, Australia. She graduated with her Bachelor of Biotechnology degree with first-class honors in the field of Drug Design and Development in 2003 from the Institute of Molecular Bioscience, The University of Queensland. Her honors thesis incorporated the analysis of protease−inhibitor structures as well as West Nile Virus NS3 protease enzymology. In 2004 she worked as Network Administrator for the protease networks www.protease.net and www.protease.net.au.

Professor David P. Fairlie received his B.Sc. (Honors) degree from the University of Adelaide and Ph.D. degree from the University of New South Wales and did postdoctoral research at Stanford University and the University of Toronto. He has held research/teaching appointments in six Australian universities and led the Chemistry Group in the Centre for Drug Design and Development, University of Queensland, since 1991. His research interests are in chemical synthesis (organic, medicinal, inorganic); molecular recognition (DNA-, RNA-, protein-, metal-binding compounds); peptide and protein mimetics; non-peptidic enzyme inhibitors and receptor antagonists for viral and parasitic infections, inflammatory disorders, cancers, and neurodegenerative diseases; and mechanisms of chemical reactions, biological processes, disease development, and drug action.

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Article Views: 1,991 Times
Received 30 July 2004
Published online 16 February 2005
Published in print 1 March 2005
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