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Releasable Luciferin−Transporter Conjugates:  Tools for the Real-Time Analysis of Cellular Uptake and Release

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Departments of Chemistry, Molecular Pharmacology, and Pediatrics, Stanford University, Stanford, California 94305-5080
Cite this: J. Am. Chem. Soc. 2006, 128, 20, 6526–6527
Publication Date (Web):April 25, 2006
https://doi.org/10.1021/ja0586283
Copyright © 2006 American Chemical Society
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    Abstract

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    The design, synthesis, and evaluation of conjugates of arginine-rich transporters and luciferin are described that release luciferin only after entry into cells that are stably transfected with luciferase. Each molecule of free luciferin that is released after entry generates a photon that can be measured allowing for real-time quantification of uptake and release in cells. The process provides a method to assay uptake and release of free luciferin as a function of variations in the releasable linker and in the transporter.

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     Department of Chemistry.

    §

     Department of Pediatrics.

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    In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

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     Departments of Chemistry and Molecular Pharmacology.

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