Abstract
The first total synthesis of (−)-lepistine has been accomplished in 11 steps from (S)-glycidol. The synthesis features construction of the 10-membered ring via an intramolecular epoxide opening by nosylamide, regioselective dehydration to form an enol ether, and construction of the aminal moiety induced by cleavage of the nosyl groups.
Supporting Information
Experimental details and spectroscopic data. This material is available free of charge via the Internet at http://pubs.acs.org.
