Bonding of Macromolecular Hydrogels Using Perturbants

Gavrielle M. Price, Kengyeh K. Chu, James G. Truslow, Min D. Tang-Schomer, Andrew P. Golden, Jerome Mertz and Joe Tien
Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215
J. Am. Chem. Soc., 2008, 130 (21), pp 6664–6665
DOI: 10.1021/ja711340d
Publication Date (Web): May 3, 2008
Copyright © 2008 American Chemical Society

Abstract

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This work describes a method to bond patterned macromolecular gels into monolithic structures using perturbants. Bonding strengths for a variety of solutes follow a Hofmeister ordering; this result and optical measurements indicate that bonding occurs by reversible perturbation of contacting gels. The resulting microfluidic gels are mechanically robust and can serve as scaffolds for cell culture.

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History

  • Published In Issue May 28, 2008
  • Article ASAPMay 03, 2008
  • Received: December 21, 2007
    Revised: April 16, 2008

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