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Communication

Bonding of Macromolecular Hydrogels Using Perturbants

Supporting Info

Gavrielle M. Price, Kengyeh K. Chu, James G. Truslow, Min D. Tang-Schomer, Andrew P. Golden, Jerome Mertz and Joe Tien

Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215

J. Am. Chem. Soc., 2008, 130 (21), pp 6664–6665

DOI: 10.1021/ja711340d

Publication Date (Web): May 3, 2008

Abstract

This work describes a method to bond patterned macromolecular gels into monolithic structures using perturbants. Bonding strengths for a variety of solutes follow a Hofmeister ordering; this result and optical measurements indicate that bonding occurs by reversible perturbation of contacting gels. The resulting microfluidic gels are mechanically robust and can serve as scaffolds for cell culture.

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