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Letter

Total Synthesis of (−)-Mucocin

Supporting Info

Michael T. Crimmins,* Yan Zhang, and Frank A. Diaz

Venable and Kenan Laboratories of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599

Org. Lett., 2006, 8 (11), pp 2369–2372

DOI: 10.1021/ol060704z

Publication Date (Web): April 26, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

An enantioselective total synthesis of (−)-mucocin has been completed. A combination of asymmetric glycolate aldol additions and ring closing metathesis reactions were exploited to construct the C18−C34 and C7−C17 fragments. A selective cross-metathesis reaction was employed as the key step to couple two complex fragments.

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Published In Issue May 25, 2006
Received March 22, 2006

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Letter

Total Synthesis of (−)-Mucocin

Abstract

Available Supporting Information for This Article

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Asymmetric Total Synthesis of Pyranicin

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Nine-Step Enantioselective Total Synthesis of (+)-Minfiensine

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