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Letter

Enantioselective Total Synthesis of (+)-SCH 351448

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Michael T. Crimmins* and Grace S. Vanier

Venable and Kenan Laboratories of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599

Org. Lett., 2006, 8 (13), pp 2887–2890

DOI: 10.1021/ol061073b

Publication Date (Web): June 2, 2006

Abstract

A stereoselective synthesis of SCH 351448 has been completed. Twelve of the fourteen stereogenic centers were established through chiral enolate reactions, and six key C−C bonds were formed by metathesis reactions.

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Published In Issue June 22, 2006
Received May 2, 2006

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Letter

Enantioselective Total Synthesis of (+)-SCH 351448

Abstract

Available Supporting Information for This Article

PDF

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History

Recommend & Share

Related Content

Palladium-Catalyzed Enantioselective Addition of Two Distinct Nucleophiles across Alkenes Capable of Quinone Methide Formation

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