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 Microscopy of the normal brain (top left) shows dark-staining neurons in the cerebral cortex with no spongy change in surrounding tissue. In classical CJD (top right), brain cortex contains numerous small vacuoles that give a spongelike appearance. In new-variant CJD (bottom left), the cortex shows less severe sponginess but contains "florid" plaques--aggregates of amloid material surrounded by spongy change. Florid plaques in new-variant CJD (bottom right) stain intensely for prion protein (brown). Courtesy of James W. Ironside, National CJD Surveillance Unit
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