| Figure 1. [15N]HSQC Spectra of the DNA-Binding Domain of the E2 Protein in the Absence (Black Contours) and Presence (Red Contours) of Ligand.
Significant chemical shift changes indicate the ligand binding by the protein, and those residues that exhibit chemical shift changes when ligand is added correlate to atoms in the ligand-binding site. (Courtesy of Stephen W. Fesik) Reprinted with permission from Science, 274, 1996, 1531-1534. Copyright 1996 American Association for the Advancement of Science. Readers may view, browse, and/or download this material for temporary copying purposes only, provided these uses are for noncommercial personal purposes. Except as provided by law, this material may not be further reproduced, distributed, transmitted, modified, adapted, performed, displayed, published or sold in whole or in part, without prior written permission from AAAS. |
