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Differential Reactivity of Purified Bioactive Coffee Furans, Cafestol and Kahweol, with Acidic Nitrite: Product Characterization and Factors Controlling Nitrosation Versus Ring-Opening Pathways

Maria De Lucia, Lucia Panzella, Dominique Melck, Italo Giudicianni, Andrea Motta, Alessandra Napolitano and Marco d’Ischia

Chem. Res. Toxicol., Articles ASAP (As Soon As Publishable)

Publication Date (Web): November 6, 2009 (Article)

DOI: 10.1021/tx900224x

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Disulfides as Cyanide Antidotes: Evidence for a New In Vivo Oxidative Pathway for Cyanide Detoxification

Mark A. Zottola, Keith Beigel, Sunil-Datta Soni and Richard Lawrence

Chem. Res. Toxicol., Articles ASAP (As Soon As Publishable)

Publication Date (Web): November 5, 2009 (Article)

DOI: 10.1021/tx900258m

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Mitochondrial-Driven Ubiquinone Enhances Extracellular Calcium-Dependent Nitric Oxide Production and Reduces Glycochenodeoxycholic Acid-Induced Cell Death in Hepatocytes

Sandra Gonzlez-Rubio, Ana B. Hidalgo, Gustavo Ferrn, Rosario I. Bello, Raul Gonzlez, Manuel D. Gahete, Isidora Ranchal, Blanca A. Rodrguez, Pilar Barrera, Patricia Aguilar-Melero, Clara I. Linares, Justo P. Castao, Victor M. Victor, Manuel De la Mata and Jordi Muntan

Chem. Res. Toxicol., Articles ASAP (As Soon As Publishable)

Publication Date (Web): November 4, 2009 (Article)

DOI: 10.1021/tx900327t

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Stereoselective Metabolism of the Environmental Mammary Carcinogen 6-Nitrochrysene to trans-1,2-Dihydroxy-1,2-dihydro-6-nitrochrysene by Aroclor 1254-Treated Rat Liver Microsomes and Their Comparative Mutation Profiles in a lacI Mammary Epithelial Cell Line

Yuan-Wan Sun, Joseph B. Guttenplan, Michael Khmelnitsky, Jacek Krzeminski, Telih Boyiri, Shantu Amin and Karam El-Bayoumy

Chem. Res. Toxicol., Articles ASAP (As Soon As Publishable)

Publication Date (Web): November 3, 2009 (Article)

DOI: 10.1021/tx9002897

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Exocyclic Deoxyadenosine Adducts of 1,2,3,4-Diepoxybutane: Synthesis, Structural Elucidation, and Mechanistic Studies

Uthpala Seneviratne, Sergey Antsypovich, Melissa Goggin, Danae Quirk Dorr, Rebecca Guza, Adam Moser, Carrie Thompson, Darrin M. York and Natalia Tretyakova

Chem. Res. Toxicol., Articles ASAP (As Soon As Publishable)

Publication Date (Web): November 2, 2009 (Article)

DOI: 10.1021/tx900312e

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Current Issue

The latest published issue of Chemical Research in Toxicology.

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In this Issue

Chem. Res. Toxicol., 2009, 22 (10), pp 1649–1650

Publication Date (Web): October 19, 2009 (In This Issue)

DOI: 10.1021/tx900308x

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Spotlight

Chem. Res. Toxicol., 2009, 22 (10), pp 1651–1652

Publication Date (Web): October 19, 2009 (Spotlight)

DOI: 10.1021/tx9002885

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A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

Don Walker, Joe Brady, Deepak Dalvie, John Davis, Martin Dowty, J. Neil Duncan, Angus Nedderman, R. Scott Obach and Pat Wright

Chem. Res. Toxicol., 2009, 22 (10), pp 1653–1662

Publication Date (Web): August 31, 2009 (Review)

DOI: 10.1021/tx900213j

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Reductive Activation of Mitomycin C by Thiols: Kinetics, Mechanism, and Biological Implications

Manuel M. Paz

Chem. Res. Toxicol., 2009, 22 (10), pp 1663–1668

Publication Date (Web): September 30, 2009 (Communication)

DOI: 10.1021/tx9002758

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Chemical Synthesis of Two Series of Nerve Agent Model Compounds and Their Stereoselective Interaction with Human Acetylcholinesterase and Human Butyrylcholinesterase

Nora H. Barakat, Xueying Zheng, Cynthia B. Gilley, Mary MacDonald, Karl Okolotowicz, John R. Cashman, Shubham Vyas, Jeremy M. Beck, Christopher M. Hadad and Jun Zhang

Chem. Res. Toxicol., 2009, 22 (10), pp 1669–1679

Publication Date (Web): August 31, 2009 (Article)

DOI: 10.1021/tx900096j

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Most Read Articles

Most Read articles are updated on a monthly basis and available as 1 month and 12 month lists. Below is a Top 5 excerpt from the 1 month list.

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Mesoporosity and Functional Group Dependent Endocytosis and Cytotoxicity of Silica Nanomaterials

Zhimin Tao, Bonnie B. Toms, Jerry Goodisman and Tewodros Asefa

Chem. Res. Toxicol., Articles ASAP (As Soon As Publishable)

Publication Date (Web): October 9, 2009 (Article)

DOI: 10.1021/tx900276u

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Cytochrome P450 and Chemical Toxicology

F. Peter Guengerich

Chem. Res. Toxicol., 2008, 21 (1), pp 70–83

Publication Date (Web): December 6, 2007 (Perspective)

DOI: 10.1021/tx700079z

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Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

Thomas A. Baillie

Chem. Res. Toxicol., 2008, 21 (1), pp 129–137

Publication Date (Web): December 4, 2007 (Perspective)

DOI: 10.1021/tx7002273

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Glyphosate Formulations Induce Apoptosis and Necrosis in Human Umbilical, Embryonic, and Placental Cells

Nora Benachour and Gilles-Eric Sralini

Chem. Res. Toxicol., 2009, 22 (1), pp 97–105

Publication Date (Web): December 23, 2008 (Article)

DOI: 10.1021/tx800218n

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Applying Mechanisms of Chemical Toxicity to Predict Drug Safety

F. Peter Guengerich and James S. MacDonald

Chem. Res. Toxicol., 2007, 20 (3), pp 344–369

Publication Date (Web): February 16, 2007 (Review)

DOI: 10.1021/tx600260a

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Most Cited Articles

Most Cited articles are updated on a monthly basis and available as Last 3 Years and All Time lists. Citation data is made available by participants in CrossRef's Cited-by Linking service. Below is an excerpt from the Last 3 Years list (published across all volumes). For a more comprehensive list of citations, users are encouraged to perform a search in SciFinder.

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Role of Quinones in Toxicology

Judy L. Bolton, Michael A. Trush, Trevor M. Penning, Glenn Dryhurst, and Terrence J. Monks

Chem. Res. Toxicol., 2000, 13 (3), pp 135–160

Publication Date (Web): February 23, 2000 (Review)

DOI: 10.1021/tx9902082

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Common and Uncommon Cytochrome P450 Reactions Related to Metabolism and Chemical Toxicity

F. Peter Guengerich

Chem. Res. Toxicol., 2001, 14 (6), pp 611–650

Publication Date (Web): May 05, 2001 (Review)

DOI: 10.1021/tx0002583

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Oxidative Damage and Tyrosine Nitration from Peroxynitrite

Joseph S. Beckman

Chem. Res. Toxicol., 1996, 9 (5), pp 836–844

Publication Date (Web): July 15, 1996 (Open Forum)

DOI: 10.1021/tx9501445

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Structure, Catalytic Mechanism, and Evolution of the Glutathione Transferases

Richard N. Armstrong

Chem. Res. Toxicol., 1997, 10 (1), pp 2–18

Publication Date (Web): January 20, 1997 (Review)

DOI: 10.1021/tx960072x

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Biochemistry, Biology, and Carcinogenicity of Tobacco-Specific N-Nitrosamines

Stephen S. Hecht

Chem. Res. Toxicol., 1998, 11 (6), pp 559–603

Publication Date (Web): June 02, 1998 (Review)

DOI: 10.1021/tx980005y

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