Now showing 1–5
View All

Just Accepted Manuscripts

Just Accepted manuscripts are peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing.

View all Just Accepted Manuscripts
Now showing 1–5
View All

Articles ASAP (As Soon As Publishable)

ASAP articles are edited and published online ahead of print.

For Selected Content:

Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure

Serena Scapecchi, Marta Nesi, Rosanna Matucci, Cristina Bellucci, Michela Buccioni, Silvia Dei, Luca Guandalini, Dina Manetti, Cecilia Martelli, Elisabetta Martini, Gabriella Marucci, Francesca Orlandi, Maria Novella Romanelli, Elisabetta Teodori and Roberto Cirilli
J. Med. Chem., Articles ASAP (As Soon As Publishable)
Publication Date (Web): November 20, 2009 (Article)
DOI: 10.1021/jm901048j

Novel Bisaryl Substituted Thiazoles and Oxazoles as Highly Potent and Selective Peroxisome Proliferator-Activated Receptor δ Agonists

Robert Epple, Christopher Cow, Yongping Xie, Mihai Azimioara, Ross Russo, Xing Wang, John Wityak, Donald S. Karanewsky, Tove Tuntland, Vn T. B. Nguy-Trn, Cara Cuc Ngo, David Huang, Enrique Saez, Tracy Spalding, Andrea Gerken, Maya Iskandar, H. Martin Seidel and Shin-Shay Tian
J. Med. Chem., Articles ASAP (As Soon As Publishable)
Publication Date (Web): November 20, 2009 (Article)
DOI: 10.1021/jm9007399

9-Arylpurines as a Novel Class of Enterovirus Inhibitors

Leire Aguado, Hendrik Jan Thibaut, Eva-Mara Priego, Mara-Luisa Jimeno, Mara-Jos Camarasa, Johan Neyts and Mara-Jess Prez-Prez
J. Med. Chem., Articles ASAP (As Soon As Publishable)
Publication Date (Web): November 19, 2009 (Article)
DOI: 10.1021/jm901240p

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

Mauro Mileni, Joie Garfunkle, Cyrine Ezzili, F. Scott Kimball, Benjamin F. Cravatt, Raymond C. Stevens and Dale L. Boger
J. Med. Chem., Articles ASAP (As Soon As Publishable)
Publication Date (Web): November 19, 2009 (Article)
DOI: 10.1021/jm9012196

Perspectives of P-Glycoprotein Modulating Agents in Oncology and Neurodegenerative Diseases: Pharmaceutical, Biological, and Diagnostic Potentials

Nicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, Marialessandra Contino, Carmela Inglese, Mauro Niso and Roberto Perrone
J. Med. Chem., Articles ASAP (As Soon As Publishable)
Publication Date (Web): November 19, 2009 (Perspective)
DOI: 10.1021/jm900743c
View all Articles ASAP
Now showing 1–5
View All

Current Issue

The latest published issue of Journal of Medicinal Chemistry.

For Selected Content:

Exploring Chemical Space with Aptamers

Michael Famulok
J. Med. Chem., 2009, 52 (22), pp 6951–6957
Publication Date (Web): October 30, 2009 (Perspective)
DOI: 10.1021/jm9014789

Synthesis, Crystallization, and Biological Evaluation of an Orally Active Prodrug of Gemcitabine

David M. Bender, Jingqi Bao, Anne H. Dantzig, William D. Diseroad, Kevin L. Law, Nicholas A. Magnus, Jeffrey A. Peterson, Everett J. Perkins, Yangwei J. Pu, Susan M. Reutzel-Edens, David M. Remick, James J. Starling, Gregory A. Stephenson, Radhe K. Vaid, Deyi Zhang and James R. McCarthy
J. Med. Chem., 2009, 52 (22), pp 6958–6961
Publication Date (Web): October 27, 2009 (Letter)
DOI: 10.1021/jm901181h

(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A Wingless β-Catenin Agonist That Increases Bone Formation Rate

Jeffrey C. Pelletier, Joseph T. Lundquist, IV, Adam M. Gilbert, Nipa Alon, Frederick J. Bex, Bheem M. Bhat, Mattew G. Bursavich, Valerie E. Coleburn, Luciana A. Felix, Daniel M. Green, Paula Green, Diane B. Hauze, Yogendra P. Kharode, Ho-Sun Lam, Susan R. Lockhead, Ronald L. Magolda, Jeanne J. Matteo, John F. Mehlmann, Colleen Milligan, Richard J. Murrills, Jennifer Pirrello, Sally Selim, Michael C. Sharp, Ray J. Unwalla, Matthew D. Vera, Jay E. Wrobel, Paul Yaworsky and Peter V. N. Bodine
J. Med. Chem., 2009, 52 (22), pp 6962–6965
Publication Date (Web): October 26, 2009 (Letter)
DOI: 10.1021/jm9014197

From Serendipity to Rational Antituberculosis Drug Discovery of Mefloquine-Isoxazole Carboxylic Acid Esters

Jialin Mao, Hai Yuan, Yuehong Wang, Baojie Wan, Marco Pieroni, Qingqing Huang, Richard B. van Breemen, Alan P. Kozikowski and Scott G. Franzblau
J. Med. Chem., 2009, 52 (22), pp 6966–6978
Publication Date (Web): October 28, 2009 (Article)
DOI: 10.1021/jm900340a

Synthetic mRNA Splicing Modulator Compounds with in Vivo Antitumor Activity

Chandraiah Lagisetti, Alan Pourpak, Tinopiwa Goronga, Qin Jiang, Xiaoli Cui, Judith Hyle, Jill M. Lahti, Stephan W. Morris and Thomas R. Webb
J. Med. Chem., 2009, 52 (22), pp 6979–6990
Publication Date (Web): October 30, 2009 (Article)
DOI: 10.1021/jm901215m
View the full Current Issue
Now showing 1–5
View All

Most Read Articles

Most Read articles are updated on a monthly basis and available as 1 month and 12 month lists. Below is a Top 5 excerpt from the 1 month list.

For Selected Content:

Kinase Inhibitor Data Modeling and de Novo Inhibitor Design with Fragment Approaches

Michal Vieth, Jon Erickson, Jibo Wang, Yue Webster, Mary Mader, Richard Higgs and Ian Watson
J. Med. Chem., 2009, 52 (20), pp 6456–6466
Publication Date (Web): September 30, 2009 (Article)
DOI: 10.1021/jm901147e

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering, Jack Bikker and Christine Humblet
J. Med. Chem., 2009, 52 (21), pp 6752–6756
Publication Date (Web): October 14, 2009 (Article)
DOI: 10.1021/jm901241e

Three-Dimensional Pharmacophore Methods in Drug Discovery

Andrew R. Leach, Valerie J. Gillet, Richard A. Lewis and Robin Taylor
J. Med. Chem., Articles ASAP (As Soon As Publishable)
Publication Date (Web): October 15, 2009 (Perspective)
DOI: 10.1021/jm900817u

Discovery of [18F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance

Ivan Greguric, Stephen R. Taylor, Delphine Denoyer, Patrice Ballantyne, Paula Berghofer, Peter Roselt, Tien Q. Pham, Filomena Mattner, Thomas Bourdier, Oliver C. Neels, Donna S. Dorow, Christian Loc’h, Rodney J. Hicks and Andrew Katsifis
J. Med. Chem., 2009, 52 (17), pp 5299–5302
Publication Date (Web): August 19, 2009 (Letter)
DOI: 10.1021/jm9008423

Discovery of Potent and Selective Inhibitors of the Mammalian Target of Rapamycin (mTOR) Kinase

Pawel Nowak, Derek C. Cole, Natasja Brooijmans, Matthew G. Bursavich, Kevin J. Curran, John W. Ellingboe, James J. Gibbons, Irwin Hollander, YongBo Hu, Joshua Kaplan, David J. Malwitz, Lourdes Toral-Barza, Jeroen C. Verheijen, Arie Zask, Wei-Guo Zhang and Ker Yu
J. Med. Chem., 2009, 52 (22), pp 7081–7089
Publication Date (Web): October 19, 2009 (Article)
DOI: 10.1021/jm9012642
View all of the Most Read Articles
Now showing 1–5
View All

Most Cited Articles

Most Cited articles are updated on a monthly basis and available as Last 3 Years and All Time lists. Citation data is made available by participants in CrossRef's Cited-by Linking service. Below is an excerpt from the Last 3 Years list (published across all volumes). For a more comprehensive list of citations, users are encouraged to perform a search in SciFinder.

For Selected Content:

The PPARs:  From Orphan Receptors to Drug Discovery

Timothy M. Willson, Peter J. Brown, Daniel D. Sternbach, and Brad R. Henke
J. Med. Chem., 2000, 43 (4), pp 527–550
Publication Date (Web): February 24, 2000 (Perspective)
DOI: 10.1021/jm990554g

A General and Fast Scoring Function for Protein−Ligand Interactions:  A Simplified Potential Approach

Ingo Muegge and Yvonne C. Martin
J. Med. Chem., 1999, 42 (5), pp 791–804
Publication Date (Web): February 24, 1999 (Article)
DOI: 10.1021/jm980536j

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw, Jeffery S. Carter, Paul W. Collins, Stephen Docter, Matthew J. Graneto, Len F. Lee, James W. Malecha, Julie M. Miyashiro, Roland S. Rogers, D. J. Rogier, Stella S. Yu, Gary D. Anderson, Earl G. Burton, J. Nita Cogburn, Susan A. Gregory, Carol M. Koboldt, William E. Perkins, Karen Seibert, Amy W. Veenhuizen, Yan Y. Zhang, and Peter C. Isakson
J. Med. Chem., 1997, 40 (9), pp 1347–1365
Publication Date (Web): April 25, 1997 (Article)
DOI: 10.1021/jm960803q

Protein-Based Virtual Screening of Chemical Databases. 1. Evaluation of Different Docking/Scoring Combinations

Caterina Bissantz, Gerd Folkers, and Didier Rognan
J. Med. Chem., 2000, 43 (25), pp 4759–4767
Publication Date (Web): November 22, 2000 (Article)
DOI: 10.1021/jm001044l

Protease Inhibitors:  Current Status and Future Prospects

Donmienne Leung, Giovanni Abbenante, and David P. Fairlie
J. Med. Chem., 2000, 43 (3), pp 305–341
Publication Date (Web): February 10, 2000 (Perspective)
DOI: 10.1021/jm990412m
View all of the Most Cited Articles
Advertisements
Info for Advertisers

Browse By Issue

List of Issues

Stay Current

Get your research ASAP.

e-Alerts | RSS Feeds RSS Feeds
Advertisements
Info for Advertisers