Journal of Medicinal Chemistry (ACS Publications)

Poly-N-methylated Amyloid β-Peptide (Aβ) C-Terminal Fragments Reduce Aβ Toxicity in Vitro and in Drosophila melanogaster

Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

Morpholine Derivatives Greatly Enhance the Selectivity of Mammalian Target of Rapamycin (mTOR) Inhibitors

Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues

Displacement Assay for the Detection of Stabilizers of Inactive Kinase Conformations

Rapid Generation of a High Quality Lead for Transforming Growth Factor-β (TGF-β) Type I Receptor (ALK5)

Identification of Lead Compounds As Antagonists of Protein Bcl-x_L with a Diversity-Oriented Multidisciplinary Approach

Carborane Derivatives Loaded into Liposomes as Efficient Delivery Systems for Boron Neutron Capture Therapy

Drug Effects Viewed from a Signal Transduction Network Perspective

Porphyrin-Cyclodextrin Conjugates as a Nanosystem for Versatile Drug Delivery and Multimodal Cancer Therapy

About the Journal

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The most cited journal in Medicinal Chemistry, publishing original research on the correlation of molecular structure to biological activity with a focus on the relationships of chemistry to biological activity.

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Just Accepted manuscripts are peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing.

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Articles ASAP (As Soon As Publishable)

ASAP articles are edited and published online ahead of print.

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Biological and Biophysical Properties of the Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Are Affected by the Presence of Short Alkyl Groups on the Phenyl Ring

rik Oger, Aur

lien Lecorgne, Elisa Sala, Vanessa Nardese, Florence Demay, Soizic Chevance, Danielle C. Desravines, Nataliia Aleksandrova, R

my Le Gu

vel, Simone Lorenzi, Andrea R. Beccari, Peter Barath, Darren J. Hart, Arnaud Bondon, Daniele Carettoni, G

rard Simonneaux and Gilles Salbert

J. Med. Chem., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 9, 2010 (Article)

DOI: 10.1021/jm901561u

Abstract | Supporting Info

Synthesis and Evaluation of Paracetamol Esters As Novel Fatty Acid Amide Hydrolase Inhibitors

Valentina Onnis, Cenzo Congiu, Emmelie Bj

rklund, Franziska Hempel, Emma S

derstr

m and Christopher J. Fowler

J. Med. Chem., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 9, 2010 (Article)

DOI: 10.1021/jm901891p

Abstract | Supporting Info

Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer

Xiong Cai, Hai-Xiao Zhai, Jing Wang, Jeffrey Forrester, Hui Qu, Ling Yin, Cheng-Jung Lai, Rudi Bao and Changgeng Qian

J. Med. Chem., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 9, 2010 (Article)

DOI: 10.1021/jm901453q

Abstract | Supporting Info

Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine_2A Inverse Agonists for the Treatment of Insomnia

Bradley R. Teegarden, Hongmei Li, Honnappa Jayakumar, Sonja Strah-Pleynet, Peter I. Dosa, Susan D. Selaya, Naomi Kato, Katie H. Elwell, Jarrod Davidson, Karen Cheng, Hazel Saldana, John M. Frazer, Kevin Whelan, Jonathan Foster, Stephan Espitia, Robert R. Webb, Nigel R. A. Beeley, William Thomsen, Stephen R. Morairty, Thomas S. Kilduff and Hussien A. Al-Shamma

J. Med. Chem., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 9, 2010 (Article)

DOI: 10.1021/jm9007328

Abstract

Identification of Potent Pyrazolo[4,3-h]quinazoline-3-carboxamides as Multi-Cyclin-Dependent Kinase Inhibitors

Gabriella Traquandi, Marina Ciomei, Dario Ballinari, Elena Casale, Nicoletta Colombo, Valter Croci, Francesco Fiorentini, Antonella Isacchi, Antonio Longo, Ciro Mercurio, Achille Panzeri, Wilma Pastori, Paolo Pevarello, Daniele Volpi, Patrick Roussel, Anna Vulpetti and Maria Gabriella Brasca

J. Med. Chem., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 8, 2010 (Article)

DOI: 10.1021/jm901710h

Abstract | Supporting Info

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Current Issue

The latest published issue of Journal of Medicinal Chemistry.

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Scope and Difficulty in Generating Theoretical Insights Regarding Ligand Recognition and Activation of the β₂ Adrenergic Receptor

Marvin A. Soriano-Urs

a, Jos

G. Trujillo-Ferrara and Jos

Correa-Basurto

J. Med. Chem., 2010, 53 (3), pp 923–932

Publication Date (Web): October 5, 2009 (Perspective)

DOI: 10.1021/jm900419a

Abstract

¹⁸F Stilbenes and Styrylpyridines for PET Imaging of Aβ Plaques in Alzheimer’s Disease: A Miniperspective

Hank F. Kung, Seok Rye Choi, Wenchao Qu, Wei Zhang and Daniel Skovronsky

J. Med. Chem., 2010, 53 (3), pp 933–941

Publication Date (Web): October 21, 2009 (Perspective)

DOI: 10.1021/jm901039z

Abstract

Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors

Yu-Sen Wang, Corey Strickland, Johannes H. Voigt, Matthew E. Kennedy, Brian M. Beyer, Mary M. Senior, Elizabeth M. Smith, Terry L. Nechuta, Vincent S. Madison, Michael Czarniecki, Brian A. McKittrick, Andrew W. Stamford, Eric M. Parker, John C. Hunter, William J. Greenlee and Daniel F. Wyss

J. Med. Chem., 2010, 53 (3), pp 942–950

Publication Date (Web): December 31, 2009 (Article)

DOI: 10.1021/jm901472u

Abstract

Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation

Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, Johannes Voigt, Corey Strickland, Elizabeth M. Smith, Jared Cumming, Lingyan Wang, Jesse Wong, Yu-Sen Wang, Daniel F. Wyss, Xia Chen, Reshma Kuvelkar, Matthew E. Kennedy, Leonard Favreau, Eric Parker, Brian A. McKittrick, Andrew Stamford, Michael Czarniecki, William Greenlee and John C. Hunter

J. Med. Chem., 2010, 53 (3), pp 951–965

Publication Date (Web): December 31, 2009 (Article)

DOI: 10.1021/jm901408p

Abstract

Antitrypanosomal Activity of 1,2-Dihydroquinolin-6-ols and Their Ester Derivatives

Jean Fotie, Marcel Kaiser, Dawn A. Delf

n, Joshua Manley, Carolyn S. Reid, Jean-Marc Paris, Tanja Wenzler, Louis Maes, Kiran V. Mahasenan, Chenglong Li and Karl A. Werbovetz

J. Med. Chem., 2010, 53 (3), pp 966–982

Publication Date (Web): January 4, 2010 (Article)

DOI: 10.1021/jm900723w

Abstract | Supporting Info

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Most Read Articles

Most Read articles are updated on a monthly basis and available as 1 month and 12 month lists. Below is a Top 5 excerpt from the 1 month list.

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Heat Shock Protein 90: Inhibitors in Clinical Trials

Marco A. Biamonte, Ryan Van de Water, Joseph W. Arndt, Robert H. Scannevin, Daniel Perret and Wen-Cherng Lee

J. Med. Chem., 2010, 53 (1), pp 3–17

Publication Date (Web): September 16, 2009 (Perspective)

DOI: 10.1021/jm9004708

Abstract

Computational Studies, Virtual Screening, and Theoretical Molecular Models

rgen Bajorath

J. Med. Chem., 2010, 53 (1), pp 1–2

Publication Date (Web): December 11, 2009 (Editorial)

DOI: 10.1021/jm901774n

Abstract

Drug Effects Viewed from a Signal Transduction Network Perspective

Anton F. Fliri, William T. Loging and Robert A. Volkmann

J. Med. Chem., 2009, 52 (24), pp 8038–8046

Publication Date (Web): November 5, 2009 (Article)

DOI: 10.1021/jm901001p

Abstract | Supporting Info

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

Manthena V. S. Varma, R. Scott Obach, Charles Rotter, Howard R. Miller, George Chang, Stefanus J. Steyn, Ayman El-Kattan and Matthew D. Troutman

J. Med. Chem., 2010, 53 (3), pp 1098–1108

Publication Date (Web): January 13, 2010 (Article)

DOI: 10.1021/jm901371v

Abstract | Supporting Info

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

Daniel P. Sutherlin, Deepak Sampath, Megan Berry, Georgette Castanedo, Zhigang Chang, Irina Chuckowree, Jenna Dotson, Adrian Folkes, Lori Friedman, Richard Goldsmith, Tim Heffron, Leslie Lee, John Lesnick, Cristina Lewis, Simon Mathieu, Jim Nonomiya, Alan Olivero, Jodie Pang, Wei Wei Prior, Laurent Salphati, Steve Sideris, Qingping Tian, Vickie Tsui, Nan Chi Wan, Shumei Wang, Christian Wiesmann, Susan Wong and Bing-Yan Zhu

J. Med. Chem., 2010, 53 (3), pp 1086–1097

Publication Date (Web): January 5, 2010 (Article)

DOI: 10.1021/jm901284w

Abstract

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Most Cited Articles

Most Cited articles are updated on a monthly basis and available as Last 3 Years and All Time lists. Citation data is made available by participants in CrossRef's Cited-by Linking service. Below is an excerpt from the Last 3 Years list (published across all volumes). For a more comprehensive list of citations, users are encouraged to perform a search in SciFinder.

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The PPARs: From Orphan Receptors to Drug Discovery

Timothy M. Willson, Peter J. Brown, Daniel D. Sternbach, and Brad R. Henke

J. Med. Chem., 2000, 43 (4), pp 527–550

Publication Date (Web): February 24, 2000 (Perspective)

DOI: 10.1021/jm990554g

Abstract

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A General and Fast Scoring Function for Protein−Ligand Interactions: A Simplified Potential Approach

Ingo Muegge and Yvonne C. Martin

J. Med. Chem., 1999, 42 (5), pp 791–804

Publication Date (Web): February 24, 1999 (Article)

DOI: 10.1021/jm980536j

Abstract | Supporting Info

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Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw, Jeffery S. Carter, Paul W. Collins, Stephen Docter, Matthew J. Graneto, Len F. Lee, James W. Malecha, Julie M. Miyashiro, Roland S. Rogers, D. J. Rogier, Stella S. Yu, Gary D. Anderson, Earl G. Burton, J. Nita Cogburn, Susan A. Gregory, Carol M. Koboldt, William E. Perkins, Karen Seibert, Amy W. Veenhuizen, Yan Y. Zhang, and Peter C. Isakson

J. Med. Chem., 1997, 40 (9), pp 1347–1365

Publication Date (Web): April 25, 1997 (Article)

DOI: 10.1021/jm960803q

Abstract

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Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Daniel F. Veber, Stephen R. Johnson, Hung-Yuan Cheng, Brian R. Smith, Keith W. Ward, and Kenneth D. Kopple

J. Med. Chem., 2002, 45 (12), pp 2615–2623

Publication Date (Web): May 11, 2002 (Article)

DOI: 10.1021/jm020017n

Abstract | Supporting Info

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Protein-Based Virtual Screening of Chemical Databases. 1. Evaluation of Different Docking/Scoring Combinations

Caterina Bissantz, Gerd Folkers, and Didier Rognan

J. Med. Chem., 2000, 43 (25), pp 4759–4767

Publication Date (Web): November 22, 2000 (Article)

DOI: 10.1021/jm001044l

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Journal of Medicinal Chemistry will no longer publish Letters. Authors wishing to submit a Letter are encouraged to submit their manuscript to ACS Medicinal Chemistry Letters.

Journal of Medicinal Chemistry changes purity requirements

Invitation to Authors: Journal of Medicinal Chemistry Perspective Series

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Join J. Med. Chem. at the 28th Camerino Symposium, May 16 - 20, 2010

The Most-Cited Journal in Medicinal Chemistry with 45,190 Total Citations

About the Journal

Just Accepted Manuscripts

Articles ASAP (As Soon As Publishable)

Biological and Biophysical Properties of the Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Are Affected by the Presence of Short Alkyl Groups on the Phenyl Ring

Synthesis and Evaluation of Paracetamol Esters As Novel Fatty Acid Amide Hydrolase Inhibitors

Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer

Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine_2A Inverse Agonists for the Treatment of Insomnia

Identification of Potent Pyrazolo[4,3-h]quinazoline-3-carboxamides as Multi-Cyclin-Dependent Kinase Inhibitors

Current Issue

Scope and Difficulty in Generating Theoretical Insights Regarding Ligand Recognition and Activation of the β₂ Adrenergic Receptor

¹⁸F Stilbenes and Styrylpyridines for PET Imaging of Aβ Plaques in Alzheimer’s Disease: A Miniperspective

Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors

Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation

Antitrypanosomal Activity of 1,2-Dihydroquinolin-6-ols and Their Ester Derivatives

Most Read Articles

Heat Shock Protein 90: Inhibitors in Clinical Trials

Computational Studies, Virtual Screening, and Theoretical Molecular Models

Drug Effects Viewed from a Signal Transduction Network Perspective

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

Most Cited Articles

The PPARs: From Orphan Receptors to Drug Discovery

A General and Fast Scoring Function for Protein−Ligand Interactions: A Simplified Potential Approach

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Protein-Based Virtual Screening of Chemical Databases. 1. Evaluation of Different Docking/Scoring Combinations

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